Opportunity Information: Apply for RFA CA 22 051
The National Institutes of Health (NIH) is soliciting applications for clinical sites to participate in the HIV/Cervical Cancer Prevention "CASCADE" Clinical Trials Network under a UG1 cooperative agreement mechanism (clinical trial required). The overall purpose of this opportunity is to strengthen and rigorously test real-world strategies that reduce breakdowns in the cervical cancer screening and treatment pathway for women living with HIV, a group that faces higher risk of persistent HPV infection and cervical precancer and may encounter added structural and clinical barriers to consistent prevention care. Rather than focusing on early-stage discovery, this network is built to evaluate practical, evidence-based interventions in the settings where they are actually delivered, so results can be translated quickly into routine practice.
The CASCADE network is designed to run pragmatic, multicenter clinical trials that target weak points along the secondary prevention continuum. In plain terms, the trials will concentrate on improving each step of the cervical cancer prevention cascade: increasing screening uptake (getting more eligible patients screened on time), improving the follow-up and management of abnormal screening results (reducing loss to follow-up and delays), expanding access to and completion of precancer treatment (so patients who need treatment can obtain it promptly), and optimizing the treatments used for cervical precancer (ensuring the chosen treatment approaches are feasible, acceptable, and effective in intended-use clinical environments). The intent is to move beyond proving that an intervention can work under ideal conditions, and instead test how well proven interventions work when implemented in busy clinics with real constraints, diverse patient needs, and variable resources.
A central deliverable from these trials is actionable evidence that can shape clinical practice guidelines and inform public health policy. NIH is explicitly positioning the network to generate results that stakeholders can use: clinicians deciding on workflow and follow-up processes, health systems designing service delivery models, and public health programs allocating resources for screening and precancer management. By focusing on interventions that are already clinically validated and then studying how to deploy them effectively and equitably, the network aims to shorten the time between evidence generation and improved prevention outcomes.
This specific funding opportunity supports six to eight Clinical Sites, each expected to provide broad, flexible (pluripotent) infrastructure capable of implementing multiple prevention trials over time. Sites will be led by clinical investigators and/or clinicians and are expected to do more than simply enroll participants. They will work closely with other network awardees during concept development and protocol development, offering practical insight on clinical importance, feasibility, workflow fit, recruitment and retention realities, and implementation barriers. Because the mechanism is a cooperative agreement (UG1), NIH typically anticipates substantial scientific and programmatic involvement with awardees, meaning funded sites should be prepared for active coordination, harmonized procedures across sites, and shared network expectations around trial conduct and data quality.
Eligibility is broad and includes many types of U.S. organizations and governmental entities, such as state, county, city/township, and special district governments; public and private institutions of higher education; independent school districts; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations (other than small businesses) and small businesses; and additional categories. The announcement also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. (foreign) entities. This breadth signals an interest in engaging clinical environments that reflect the diversity of communities affected by HIV and cervical cancer disparities.
Key administrative details from the notice include the funding opportunity number RFA-CA-22-051, the NIH as the sponsoring agency, and a cooperative agreement as the funding instrument. The activity category is listed under education and health, and the CFDA numbers associated with the opportunity are 93.393, 93.395, and 93.399. The original closing date shown is December 28, 2022, and the opportunity record creation date is October 3, 2022. The award ceiling and expected number of awards are not specified in the provided source text, though the narrative description indicates NIH anticipated funding six to eight clinical sites through the UG1 mechanism.
Overall, this opportunity is best understood as NIH building a coordinated set of clinical sites that can rapidly test and refine real-world approaches to make cervical cancer screening, follow-up, and precancer treatment more reliable for women living with HIV. The network structure is meant to ensure that trials are clinically grounded, feasible across multiple sites, and focused on outcomes that matter for implementation, guideline refinement, and policy decisions.Apply for RFA CA 22 051
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Clinical Sites for HIV/Cervical Cancer Prevention 'CASCADE' Clinical Trials Network (UG1 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.395, 93.399.
- This funding opportunity was created on 2022-10-03.
- Applicants must submit their applications by 2022-12-28. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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