Opportunity Information: Apply for PAR 22 181
The NIH funding opportunity PAR-22-181, titled "Research Opportunities for New and 'At-Risk' Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)," supports independent research projects through the R01 grant mechanism. The central goal is to strengthen and diversify the biomedical and behavioral research workforce by providing support to investigators who are early in their careers ("New Investigators") and to "At-Risk" investigators, particularly those from diverse backgrounds and groups that are underrepresented in the health-related sciences. Projects proposed under this announcement must fall within the scientific missions of the participating NIH Institutes and Centers, meaning applicants need to align their research aims with the priorities of the relevant NIH program areas. Clinical trials may be included, but they are not required, which allows investigators to propose either clinical trial or non-clinical trial research depending on what best fits the scientific question.
This FOA is explicitly designed to broaden participation in NIH-funded research, and it encourages applications from investigators who contribute to diversity as described in NIH diversity guidance (for example, the NIH Notice of Interest in Diversity, NOT-OD-20-031). The announcement highlights particular encouragement for investigators in specific categories (referred to as categories A and B in the full FOA) to coordinate with their institutions when applying, reflecting an emphasis on institutional support and alignment with eligibility and career-stage definitions that NIH uses for these investigator groups.
A wide range of applicant organizations are eligible. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations (both with and without 501(c)(3) status) that are not institutions of higher education; for-profit organizations other than small businesses; and small businesses. The FOA also calls out additional eligible applicant types that align with the diversity-focused purpose of the program, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments that are not federally recognized, and U.S. territories or possessions.
There are important restrictions related to foreign involvement. While "foreign components" as defined by the NIH Grants Policy Statement are allowed (meaning certain parts of the work can be performed abroad under NIH rules), non-U.S. entities applying directly as the applicant organization are not eligible under this opportunity, and non-domestic (non-U.S.) components of U.S. organizations are also stated as not eligible to apply. In practice, this means the applicant institution must be U.S.-based and meet NIH eligibility requirements, even though some foreign collaboration may still be possible when structured as an allowable foreign component.
Administratively, this is a discretionary grant opportunity administered by the National Institutes of Health. The opportunity falls under the broader activity categories of education and health, and is associated with CFDA numbers 93.242, 93.279, and 93.853. The FOA was created on June 9, 2022, and the listed original closing date is June 6, 2025. An award ceiling is not specified in the provided details, and expected award counts are not listed here, so applicants typically need to consult the full FOA and the participating NIH Institute/Center budgets and policies for realistic funding expectations and any institute-specific constraints.
Overall, this opportunity functions as a standard NIH R01 aimed at supporting independent, mission-relevant research, but with a clear workforce development emphasis: helping new and at-risk investigators from underrepresented and diverse backgrounds secure major research support, build stable research programs, and remain competitive in the NIH funding ecosystem.Apply for PAR 22 181
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.279, 93.853.
- This funding opportunity was created on 2022-06-09.
- Applicants must submit their applications by 2025-06-06. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Point-of-Care Technologies Research Network: Technology Research and Development Centers (TRDC) (U54 Clinical Trial Optional) Apply for PAR 22 203 Funding Number: PAR 22 203 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,200,000 |
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