Opportunity Information: Apply for PAR 22 181
The NIH funding opportunity PAR-22-181, titled "Research Opportunities for New and 'At-Risk' Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)," supports independent research projects through the R01 grant mechanism. The central goal is to strengthen and diversify the biomedical and behavioral research workforce by providing support to investigators who are early in their careers ("New Investigators") and to "At-Risk" investigators, particularly those from diverse backgrounds and groups that are underrepresented in the health-related sciences. Projects proposed under this announcement must fall within the scientific missions of the participating NIH Institutes and Centers, meaning applicants need to align their research aims with the priorities of the relevant NIH program areas. Clinical trials may be included, but they are not required, which allows investigators to propose either clinical trial or non-clinical trial research depending on what best fits the scientific question.
This FOA is explicitly designed to broaden participation in NIH-funded research, and it encourages applications from investigators who contribute to diversity as described in NIH diversity guidance (for example, the NIH Notice of Interest in Diversity, NOT-OD-20-031). The announcement highlights particular encouragement for investigators in specific categories (referred to as categories A and B in the full FOA) to coordinate with their institutions when applying, reflecting an emphasis on institutional support and alignment with eligibility and career-stage definitions that NIH uses for these investigator groups.
A wide range of applicant organizations are eligible. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations (both with and without 501(c)(3) status) that are not institutions of higher education; for-profit organizations other than small businesses; and small businesses. The FOA also calls out additional eligible applicant types that align with the diversity-focused purpose of the program, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments that are not federally recognized, and U.S. territories or possessions.
There are important restrictions related to foreign involvement. While "foreign components" as defined by the NIH Grants Policy Statement are allowed (meaning certain parts of the work can be performed abroad under NIH rules), non-U.S. entities applying directly as the applicant organization are not eligible under this opportunity, and non-domestic (non-U.S.) components of U.S. organizations are also stated as not eligible to apply. In practice, this means the applicant institution must be U.S.-based and meet NIH eligibility requirements, even though some foreign collaboration may still be possible when structured as an allowable foreign component.
Administratively, this is a discretionary grant opportunity administered by the National Institutes of Health. The opportunity falls under the broader activity categories of education and health, and is associated with CFDA numbers 93.242, 93.279, and 93.853. The FOA was created on June 9, 2022, and the listed original closing date is June 6, 2025. An award ceiling is not specified in the provided details, and expected award counts are not listed here, so applicants typically need to consult the full FOA and the participating NIH Institute/Center budgets and policies for realistic funding expectations and any institute-specific constraints.
Overall, this opportunity functions as a standard NIH R01 aimed at supporting independent, mission-relevant research, but with a clear workforce development emphasis: helping new and at-risk investigators from underrepresented and diverse backgrounds secure major research support, build stable research programs, and remain competitive in the NIH funding ecosystem.Apply for PAR 22 181
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.279, 93.853.
- This funding opportunity was created on 2022-06-09.
- Applicants must submit their applications by 2025-06-06. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIH PAR-22-181 (R01 Clinical Trial Optional)
What is PAR-22-181?
PAR-22-181 is an NIH funding opportunity titled "Research Opportunities for New and 'At-Risk' Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional)." It supports independent research projects using the NIH R01 grant mechanism, with an emphasis on strengthening and diversifying the biomedical and behavioral research workforce.
What is the main purpose of this funding opportunity?
The central goal is to promote workforce diversity by supporting investigators who are early in their careers ("New Investigators") and "At-Risk" investigators, particularly those from diverse backgrounds and groups underrepresented in the health-related sciences, so they can build stable, competitive research programs.
What type of grant mechanism does this program use?
This opportunity uses the NIH R01 mechanism, which is intended to support independent, mission-relevant research projects.
Are clinical trials required under this FOA?
No. Clinical trials may be included but are not required. The FOA is "Clinical Trial Optional," meaning applicants may propose either clinical trial or non-clinical trial research depending on what best fits the scientific question.
What kinds of research projects are eligible?
Projects must fall within the scientific missions of the participating NIH Institutes and Centers. Applicants should align their research aims with the priorities of the relevant NIH program areas.
Who is this FOA designed to support?
It is designed to support New Investigators and At-Risk investigators, with explicit intent to broaden participation in NIH-funded research and promote workforce diversity.
Does the FOA encourage applications from investigators who contribute to diversity?
Yes. The announcement explicitly encourages applications from investigators who contribute to diversity as described in NIH diversity guidance (for example, the NIH Notice of Interest in Diversity, NOT-OD-20-031).
What are "New Investigators" and "At-Risk" investigators in this context?
The FOA targets investigators who are early in their careers ("New Investigators") and "At-Risk" investigators. Specific eligibility and career-stage definitions are tied to NIH definitions and the full FOA text (including references to categories A and B).
What are categories A and B mentioned in the FOA?
The opportunity notes particular encouragement for investigators in categories A and B (as defined in the full FOA) to coordinate with their institutions when applying. This reflects an emphasis on institutional support and alignment with NIH eligibility and career-stage definitions for the targeted investigator groups.
What kinds of organizations are eligible to apply?
A wide range of applicant organizations are eligible, including government entities, education institutions, nonprofits, and for-profits (including small businesses), as long as they meet the FOA requirements and NIH eligibility rules.
Are state and local governments eligible to apply?
Yes. Eligible applicants include state, county, city, township, and special district governments.
Are public and private universities eligible?
Yes. Public and state-controlled institutions of higher education and private institutions of higher education are listed as eligible applicants.
Are independent school districts eligible?
Yes. Independent school districts are included among eligible applicants.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations with or without 501(c)(3) status (that are not institutions of higher education) are listed as eligible applicants.
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses are eligible, and small businesses are also eligible under this FOA.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments are eligible, as are Native American tribal organizations other than federally recognized tribal governments. The FOA also references Indian/Native American tribal governments that are not federally recognized as eligible applicant types.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included among the additional eligible applicant types called out in the opportunity.
Does the FOA highlight institution types tied to workforce diversity goals?
Yes. The opportunity calls out additional eligible applicant types aligned with the diversity-focused purpose of the program, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, TCCUs, and faith-based or community-based organizations, among others.
Are eligible federal agencies allowed to apply?
Yes. Eligible federal agencies are included among the additional eligible applicant types listed.
Are regional organizations eligible to apply?
Yes. Regional organizations are included among the additional eligible applicant types mentioned in the opportunity details.
Can a non-U.S. (foreign) organization apply directly as the applicant?
No. Non-U.S. entities applying directly as the applicant organization are not eligible under this opportunity.
Can a U.S. organization with a non-U.S. component apply?
The details state that non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply. However, the FOA also indicates that "foreign components" (as defined by the NIH Grants Policy Statement) are allowed, meaning certain parts of the work may be performed abroad if structured as an allowable foreign component under NIH rules.
Are foreign components allowed at all?
Yes. Foreign components, as defined by the NIH Grants Policy Statement, are allowed. The applicant institution must still be U.S.-based and meet NIH eligibility requirements.
Which agency administers this opportunity?
This is a discretionary grant opportunity administered by the National Institutes of Health (NIH).
What are the activity categories associated with this opportunity?
The opportunity falls under the broader activity categories of education and health.
What CFDA numbers are associated with this FOA?
The opportunity is associated with CFDA numbers 93.242, 93.279, and 93.853.
When was this FOA created?
The FOA was created on June 9, 2022.
What is the listed original closing date?
The listed original closing date is June 6, 2025.
Is there an award ceiling listed?
No. An award ceiling is not specified in the provided details.
How many awards are expected?
Expected award counts are not listed in the provided details. Applicants typically need to consult the full FOA and participating NIH Institute/Center policies for realistic expectations.
How should applicants think about budget and institute-specific constraints?
Because an award ceiling and expected award counts are not provided here, applicants generally need to consult the full FOA and the participating NIH Institutes and Centers budgets and policies for realistic funding expectations and any institute-specific constraints.
What is the overall character of this funding opportunity?
It functions like a standard NIH R01 supporting independent, mission-relevant research, but with a clear workforce development emphasis: helping new and at-risk investigators from underrepresented and diverse backgrounds secure major research support, build stable research programs, and remain competitive in the NIH funding ecosystem.
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