Opportunity Information: Apply for PAR 19 287
The National Cancer Institute (NCI) is offering a cooperative agreement opportunity titled "Research Projects in Cancer Systems Biology (U01 Clinical Trial Optional)" under funding opportunity number PAR-19-287. This program sits within NCI's Cancer Systems Biology Consortium (CSBC), a larger network that includes U54 CSBC Research Centers and a U24 Coordinating Center. The specific purpose of this U01 mechanism is to support well-defined, discrete, and tightly scoped research projects that contribute to the broader CSBC goal of using systems biology to deepen understanding of how cancers start, evolve, and respond to treatment.
A central expectation of this opportunity is true integration between experimental cancer biology and computational or mathematical modeling. Projects are not meant to be purely data-generation efforts or purely in silico model-building exercises. Instead, applicants are expected to use computational models to develop or refine hypotheses and then test and validate those hypotheses through experiments, with results feeding back to improve the models. The emphasis is on iterative, tightly linked cycles of modeling and experimentation that can reveal underlying mechanisms of cancer initiation, progression, and therapeutic response. Because the consortium is explicitly interdisciplinary, proposed teams are expected to bring together complementary expertise, commonly combining cancer biologists with engineers, physicists, mathematicians, statisticians, computer scientists, and other relevant specialists, in a way that is essential to the scientific approach rather than simply additive.
The award mechanism is a U01 cooperative agreement, meaning NCI is likely to have substantial scientific or programmatic involvement during the project period compared to a standard research project grant. In practice, this often means closer coordination with NCI priorities and with the consortium structure, along with expectations for collaboration, sharing, and alignment with CSBC goals. The listing indicates "Clinical Trial Optional," which generally means a project may include a clinical trial component if scientifically justified, but a clinical trial is not required to apply.
In terms of who can apply, eligibility is broad and spans many organization types. Eligible applicants include state and county governments; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (both with and without 501(c)(3) status) that are not institutions of higher education; for-profit organizations other than small businesses; small businesses; and other entities. The opportunity also explicitly calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations). The sponsoring agency is the National Institutes of Health (NIH), with CFDA numbers 93.395 and 93.396, and the activity category is listed under education and health.
The posting includes an award ceiling of $400,000, indicating an upper bound on funding per award as provided in the source data. The opportunity was created on May 22, 2019, and shows an original closing date of January 28, 2022. Overall, the program is aimed at funding rigorous, mechanism-focused cancer systems biology projects where the defining feature is the explicit, testable connection between computational modeling and experimental validation, carried out by an interdisciplinary team and aligned with the CSBC consortium framework.Apply for PAR 19 287
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Research Projects in Cancer Systems Biology (U01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.395, 93.396.
- This funding opportunity was created on 2019-05-22.
- Applicants must submit their applications by 2022-01-28. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- Eligible applicants include: State governments, County governments, Public and State controlled institutions of higher education, Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "Research Projects in Cancer Systems Biology (U01 Clinical Trial Optional)."
What is the funding opportunity number?
The funding opportunity number is PAR-19-287.
Which agency is sponsoring this opportunity?
The sponsoring agency is the National Institutes of Health (NIH), through the National Cancer Institute (NCI).
What program or consortium is this opportunity associated with?
This opportunity is part of NCI's Cancer Systems Biology Consortium (CSBC), which includes U54 CSBC Research Centers and a U24 Coordinating Center.
What is the purpose of the U01 mechanism in this program?
The U01 mechanism is intended to support well-defined, discrete, and tightly scoped research projects that contribute to the broader CSBC goal of applying systems biology to understand how cancers start, evolve, and respond to treatment.
What scientific approach is this program emphasizing?
The program emphasizes true integration of experimental cancer biology with computational or mathematical modeling, with iterative cycles where models generate or refine hypotheses, experiments test those hypotheses, and results feed back to improve the models.
Are purely experimental (data-generation only) projects responsive to this opportunity?
Based on the stated expectations, projects are not meant to be purely data-generation efforts; they are expected to incorporate tightly linked computational modeling and experimental validation.
Are purely computational or in silico modeling projects responsive to this opportunity?
Based on the stated expectations, projects are not meant to be purely in silico model-building exercises; they are expected to include experimental testing and validation with feedback to improve the models.
What does "iterative, tightly linked cycles of modeling and experimentation" mean in this context?
It means applicants are expected to use computational or mathematical models to develop or refine testable hypotheses, run experiments to validate those hypotheses, and then use experimental results to refine the models, repeating this loop to uncover mechanisms related to cancer biology.
What kinds of cancer-related questions is this opportunity trying to address?
The opportunity is focused on projects that deepen understanding of cancer initiation, progression/evolution, and response to treatment, with an emphasis on revealing underlying mechanisms through systems biology approaches.
Is an interdisciplinary team required?
The opportunity is explicitly interdisciplinary and expects teams to bring complementary expertise (for example, cancer biology combined with engineering, physics, mathematics, statistics, computer science, or related fields) in a way that is essential to the proposed approach.
Does the opportunity allow clinical trials?
Yes. The listing indicates "Clinical Trial Optional," meaning a project may include a clinical trial component if scientifically justified, but a clinical trial is not required to apply.
What is the award mechanism and what does it imply?
The award mechanism is a U01 cooperative agreement. This generally implies that NCI is likely to have substantial scientific or programmatic involvement during the project period compared to a standard research project grant, including closer coordination with NCI priorities and alignment with the consortium structure.
What expectations are described regarding collaboration and alignment with the consortium?
The description indicates expectations for collaboration, sharing, and alignment with CSBC goals, consistent with participation in a larger consortium structure.
Who is eligible to apply?
Eligibility is broad and includes state and county governments; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status) that are not institutions of higher education; for-profit organizations other than small businesses; small businesses; and other entities.
Are minority-serving institutions included in the eligible applicant categories?
Yes. The opportunity explicitly lists eligible categories that include Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Can federal agencies apply?
Yes. The eligibility description explicitly includes eligible federal agencies.
Are U.S. territories or possessions eligible to apply?
Yes. U.S. territories or possessions are explicitly listed among eligible applicant categories.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligibility description explicitly includes non-domestic (non-U.S.) entities (foreign organizations).
What is the maximum award amount listed for this opportunity?
The posting includes an award ceiling of $400,000, indicating an upper bound on funding per award as provided in the source data.
What are the CFDA numbers associated with this opportunity?
The CFDA numbers listed are 93.395 and 93.396.
What activity category is this opportunity listed under?
The activity category is listed under education and health.
When was this opportunity created?
The opportunity was created on May 22, 2019.
What was the original closing date shown in the posting?
The posting shows an original closing date of January 28, 2022.
How does this U01 relate to other CSBC components like U54 and U24 awards?
This U01 opportunity supports discrete, tightly scoped projects that contribute to the larger CSBC network, which also includes U54 CSBC Research Centers and a U24 Coordinating Center.
What is the defining feature of a strong, responsive project for this opportunity?
The defining feature described is an explicit, testable connection between computational modeling and experimental validation, carried out in an iterative way by an interdisciplinary team and aligned with the CSBC consortium framework.
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| Exploiting In Vivo Precision Pharmacology Techniques to Understand Opioid Receptor Signaling in Specific Circuits, Cell Types, and Subcellular Compartments (R61/R33 - Clinical Trial Not Allowed) Apply for RFA DA 20 019 Funding Number: RFA DA 20 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| NCI Research Specialist (Core-based Scientist) Award (R50 Clinical Trial Not Allowed) Apply for PAR 19 290 Funding Number: PAR 19 290 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Research Specialist (Laboratory-based Scientist) Award (R50 Clinical Trial Not Allowed) Apply for PAR 19 291 Funding Number: PAR 19 291 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Development of Clinical Outcome Assessments for Clinical Trials in Substance Use Disorders as FDA-qualified Drug Development Tools (U01 Clinical Trial Optional) Apply for RFA DA 20 015 Funding Number: RFA DA 20 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Leveraging Big Data Science to Elucidate the Mechanisms of HIV Activity and Interaction with Substance Use Disorder (R21 - Clinical Trials Not Allowed) Apply for RFA DA 20 009 Funding Number: RFA DA 20 009 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Leveraging Big Data Science to Elucidate the Mechanisms of HIV Activity and Interaction with Substance Use Disorder (R01 - Clinical Trials Not Allowed) Apply for RFA DA 20 008 Funding Number: RFA DA 20 008 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Novel Technology Tools to Facilitate Research Using Next Generation Patient-derived Cancer Models (U01 Clinical Trial Not Allowed) Apply for RFA CA 19 055 Funding Number: RFA CA 19 055 Agency: National Institutes of Health Category: Education, Health Funding Amount: $700,000 |
| Cancer Prevention Clinical Trials Network (CP-CTNet): CP-CTNet Sites (UG1 Clinical Trial Required) Apply for RFA CA 19 031 Funding Number: RFA CA 19 031 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Stimulating Innovations in Behavioral Intervention Research for Cancer Prevention and Control (R21 Clinical Trial Optional) Apply for PAR 19 309 Funding Number: PAR 19 309 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
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| Leveraging Big Data Science to Elucidate the Neural Mechanisms of Addiction and Substance Use Disorder (R01 - Clinical Trials Not Allowed) Apply for RFA DA 20 006 Funding Number: RFA DA 20 006 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Leveraging Big Data Science to Elucidate the Neural Mechanisms of Addiction and Substance Use Disorder (R21 - Clinical Trials Not Allowed) Apply for RFA DA 20 007 Funding Number: RFA DA 20 007 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Modeling HIV Neuropathology Using Microglia from Human iPSC and Cerebral Organoids (R01 Clinical Trial Not Allowed) Apply for RFA DA 20 023 Funding Number: RFA DA 20 023 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| The NCI Predoctoral to Postdoctoral Fellow Transition Award (F99/K00) Apply for RFA CA 19 057 Funding Number: RFA CA 19 057 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Strategic Alliances for Medications Development to Treat Substance Use Disorders (R01-Clinical Trial Optional) Apply for PAR 19 318 Funding Number: PAR 19 318 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Participant Engagement and Cancer Genome Sequencing (PE-CGS): Research Centers (U2C Clinical Trial Optional) Apply for RFA CA 19 045 Funding Number: RFA CA 19 045 Agency: National Institutes of Health Category: Education, Health Funding Amount: $2,500,000 |
| Participant Engagement and Cancer Genome Sequencing (PE-CGS): Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA CA 19 046 Funding Number: RFA CA 19 046 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
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