Opportunity Information: Apply for PAR 19 287
The National Cancer Institute (NCI) is offering a cooperative agreement opportunity titled "Research Projects in Cancer Systems Biology (U01 Clinical Trial Optional)" under funding opportunity number PAR-19-287. This program sits within NCI's Cancer Systems Biology Consortium (CSBC), a larger network that includes U54 CSBC Research Centers and a U24 Coordinating Center. The specific purpose of this U01 mechanism is to support well-defined, discrete, and tightly scoped research projects that contribute to the broader CSBC goal of using systems biology to deepen understanding of how cancers start, evolve, and respond to treatment.
A central expectation of this opportunity is true integration between experimental cancer biology and computational or mathematical modeling. Projects are not meant to be purely data-generation efforts or purely in silico model-building exercises. Instead, applicants are expected to use computational models to develop or refine hypotheses and then test and validate those hypotheses through experiments, with results feeding back to improve the models. The emphasis is on iterative, tightly linked cycles of modeling and experimentation that can reveal underlying mechanisms of cancer initiation, progression, and therapeutic response. Because the consortium is explicitly interdisciplinary, proposed teams are expected to bring together complementary expertise, commonly combining cancer biologists with engineers, physicists, mathematicians, statisticians, computer scientists, and other relevant specialists, in a way that is essential to the scientific approach rather than simply additive.
The award mechanism is a U01 cooperative agreement, meaning NCI is likely to have substantial scientific or programmatic involvement during the project period compared to a standard research project grant. In practice, this often means closer coordination with NCI priorities and with the consortium structure, along with expectations for collaboration, sharing, and alignment with CSBC goals. The listing indicates "Clinical Trial Optional," which generally means a project may include a clinical trial component if scientifically justified, but a clinical trial is not required to apply.
In terms of who can apply, eligibility is broad and spans many organization types. Eligible applicants include state and county governments; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (both with and without 501(c)(3) status) that are not institutions of higher education; for-profit organizations other than small businesses; small businesses; and other entities. The opportunity also explicitly calls out additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations). The sponsoring agency is the National Institutes of Health (NIH), with CFDA numbers 93.395 and 93.396, and the activity category is listed under education and health.
The posting includes an award ceiling of $400,000, indicating an upper bound on funding per award as provided in the source data. The opportunity was created on May 22, 2019, and shows an original closing date of January 28, 2022. Overall, the program is aimed at funding rigorous, mechanism-focused cancer systems biology projects where the defining feature is the explicit, testable connection between computational modeling and experimental validation, carried out by an interdisciplinary team and aligned with the CSBC consortium framework.Apply for PAR 19 287
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Research Projects in Cancer Systems Biology (U01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.395, 93.396.
- This funding opportunity was created on 2019-05-22.
- Applicants must submit their applications by 2022-01-28. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $400,000.00 in funding.
- Eligible applicants include: State governments, County governments, Public and State controlled institutions of higher education, Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| The Electronic Medical Records and Genomics (eMERGE): Genomic Risk Assessment and Management Network - Clinical Sites (U01 Clinical Trial Required) Apply for RFA HG 19 013 Funding Number: RFA HG 19 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploiting In Vivo Precision Pharmacology Techniques to Understand Opioid Receptor Signaling in Specific Circuits, Cell Types, and Subcellular Compartments (R61/R33 - Clinical Trial Not Allowed) Apply for RFA DA 20 019 Funding Number: RFA DA 20 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| National Drug Early Warning System Coordinating Center (U01 Clinical Trial Optional ) Apply for RFA DA 20 016 Funding Number: RFA DA 20 016 Agency: National Institutes of Health Category: Education, Health Funding Amount: $550,000 |
| NCI Research Specialist (Core-based Scientist) Award (R50 Clinical Trial Not Allowed) Apply for PAR 19 290 Funding Number: PAR 19 290 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NCI Research Specialist (Laboratory-based Scientist) Award (R50 Clinical Trial Not Allowed) Apply for PAR 19 291 Funding Number: PAR 19 291 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Development of Clinical Outcome Assessments for Clinical Trials in Substance Use Disorders as FDA-qualified Drug Development Tools (U01 Clinical Trial Optional) Apply for RFA DA 20 015 Funding Number: RFA DA 20 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Leveraging Big Data Science to Elucidate the Mechanisms of HIV Activity and Interaction with Substance Use Disorder (R21 - Clinical Trials Not Allowed) Apply for RFA DA 20 009 Funding Number: RFA DA 20 009 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Leveraging Big Data Science to Elucidate the Mechanisms of HIV Activity and Interaction with Substance Use Disorder (R01 - Clinical Trials Not Allowed) Apply for RFA DA 20 008 Funding Number: RFA DA 20 008 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Novel Technology Tools to Facilitate Research Using Next Generation Patient-derived Cancer Models (U01 Clinical Trial Not Allowed) Apply for RFA CA 19 055 Funding Number: RFA CA 19 055 Agency: National Institutes of Health Category: Education, Health Funding Amount: $700,000 |
| Cancer Prevention Clinical Trials Network (CP-CTNet): CP-CTNet Sites (UG1 Clinical Trial Required) Apply for RFA CA 19 031 Funding Number: RFA CA 19 031 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Stimulating Innovations in Behavioral Intervention Research for Cancer Prevention and Control (R21 Clinical Trial Optional) Apply for PAR 19 309 Funding Number: PAR 19 309 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Behavioral Science Track Award for Rapid Transition (B/Start)(R03 Clinical Trial Optional) Apply for PAR 19 310 Funding Number: PAR 19 310 Agency: National Institutes of Health Category: Education, Health Funding Amount: $75,000 |
| Leveraging Big Data Science to Elucidate the Neural Mechanisms of Addiction and Substance Use Disorder (R01 - Clinical Trials Not Allowed) Apply for RFA DA 20 006 Funding Number: RFA DA 20 006 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Leveraging Big Data Science to Elucidate the Neural Mechanisms of Addiction and Substance Use Disorder (R21 - Clinical Trials Not Allowed) Apply for RFA DA 20 007 Funding Number: RFA DA 20 007 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Modeling HIV Neuropathology Using Microglia from Human iPSC and Cerebral Organoids (R01 Clinical Trial Not Allowed) Apply for RFA DA 20 023 Funding Number: RFA DA 20 023 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| The NCI Predoctoral to Postdoctoral Fellow Transition Award (F99/K00) Apply for RFA CA 19 057 Funding Number: RFA CA 19 057 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Strategic Alliances for Medications Development to Treat Substance Use Disorders (R01-Clinical Trial Optional) Apply for PAR 19 318 Funding Number: PAR 19 318 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Participant Engagement and Cancer Genome Sequencing (PE-CGS): Research Centers (U2C Clinical Trial Optional) Apply for RFA CA 19 045 Funding Number: RFA CA 19 045 Agency: National Institutes of Health Category: Education, Health Funding Amount: $2,500,000 |
| Participant Engagement and Cancer Genome Sequencing (PE-CGS): Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA CA 19 046 Funding Number: RFA CA 19 046 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01 Clinical Trial Optional) Apply for PAR 19 325 Funding Number: PAR 19 325 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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