Opportunity Information: Apply for PAR 17 047
The National Institutes of Health (NIH) funding opportunity titled "Selective Cell and Network Vulnerability in Aging and Alzheimers Disease (R01)" (Funding Opportunity Number PAR-17-047) supports research aimed at pinpointing which specific brain cell types, neural circuits, and larger brain networks are especially susceptible to normal brain aging and to Alzheimers disease (AD). The central scientific idea behind the announcement is that AD does not damage the brain uniformly. Instead, certain neurons, supporting cell populations, circuits, and regions show earlier or more severe degeneration. This FOA is focused on defining and characterizing that selective vulnerability across multiple biological scales, from individual cells up through circuits and whole-brain systems, because understanding why some elements fail while others remain comparatively resilient is considered essential for accurately mapping the disease process and for identifying more effective therapeutic strategies.
This opportunity uses the NIH R01 mechanism, meaning it is intended for hypothesis-driven, multi-year research projects that can produce substantial advances in knowledge about AD-related neurobiology. Projects responsive to this FOA would generally be expected to clarify which neural components are most vulnerable, describe how that vulnerability emerges or progresses over time, and illuminate underlying mechanisms that connect cellular changes to circuit dysfunction and network-level breakdown. The emphasis on "cells to networks" highlights that the NIH is encouraging work that does not stop at describing pathology in isolated brain areas, but instead explains how cellular-level susceptibility translates into disrupted communication across circuits and broader brain networks implicated in cognitive decline and other AD symptoms.
The opportunity is categorized as discretionary funding, with the activity category listed as health, and it is associated with CFDA number 93.866. The sponsor is the National Institutes of Health. The source information provided lists an original closing date of 2018-03-06 and a creation date of 2016-11-03. While an award ceiling is not specified in the provided data, the R01 mechanism typically allows budgets and project scopes that fit the scientific aims and NIH policy constraints, and applicants generally frame their requests based on the level of work needed to achieve the proposed objectives.
Eligibility is broad and includes many common applicant types across government, academia, nonprofit, and industry. Eligible applicants include state governments; county governments; city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments that are federally recognized; public housing authorities and Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofits with 501(c)(3) status; nonprofits without 501(c)(3) status (in both cases other than institutions of higher education); for-profit organizations other than small businesses; and small businesses. In addition, the FOA explicitly notes other eligible applicants, underscoring an intent to include a wide range of institutions and communities in AD research. These additional eligible groups include Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Indian/Native American Tribal Governments other than federally recognized; eligible federal agencies; faith-based or community-based organizations; regional organizations; U.S. territories or possessions; and non-domestic (non-U.S.) entities, meaning foreign organizations may also apply.
In practical terms, the FOA is meant to push the field toward a more precise map of where and why AD-related degeneration starts and spreads, and what differentiates vulnerable versus resilient cell populations and networks during aging and AD. By prioritizing selective vulnerability, the announcement is aligned with the broader goal of moving beyond generalized descriptions of AD pathology and toward mechanistic insights that can guide targeted interventions, whether those interventions aim to protect high-risk cell types, stabilize critical circuits, preserve network connectivity, or interrupt the biological cascades that link aging processes to Alzheimers-specific neurodegeneration.Apply for PAR 17 047
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Selective Cell and Network Vulnerability in Aging and Alzheimers Disease (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2016-11-03.
- Applicants must submit their applications by 2018-03-06. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: Selective Cell and Network Vulnerability in Aging and Alzheimers Disease (R01) - PAR-17-047
What is the title and funding opportunity number for this NIH grant?
The opportunity is titled "Selective Cell and Network Vulnerability in Aging and Alzheimers Disease (R01)" and the Funding Opportunity Number (FOA) is PAR-17-047.
Which agency sponsors this funding opportunity?
The sponsor is the National Institutes of Health (NIH).
What research focus does this FOA support?
This FOA supports research aimed at identifying which specific brain cell types, neural circuits, and larger brain networks are especially susceptible to normal brain aging and to Alzheimers disease (AD).
What is meant by "selective vulnerability" in the context of Alzheimers disease?
The FOA is based on the idea that AD does not affect the brain uniformly. Instead, certain neurons, supporting cell populations, circuits, and brain regions show earlier or more severe degeneration than others. The goal is to define and characterize why some elements are vulnerable while others are comparatively resilient.
What biological scales are emphasized in this funding opportunity?
The FOA emphasizes a "cells to networks" approach, encouraging studies spanning multiple scales: individual cells, circuits, and whole-brain systems/networks.
What type of grant mechanism is used for this opportunity?
This opportunity uses the NIH R01 mechanism, which is intended for hypothesis-driven, multi-year research projects designed to produce substantial advances in knowledge.
What kinds of projects are considered responsive to the FOA?
Projects are generally expected to: (1) clarify which neural components are most vulnerable, (2) describe how vulnerability emerges or progresses over time, and (3) illuminate mechanisms linking cellular changes to circuit dysfunction and network-level breakdown.
Does the FOA encourage research beyond isolated brain regions?
Yes. The FOA encourages work that does not stop at describing pathology in isolated brain areas, but instead explains how cellular susceptibility translates into disrupted communication across circuits and broader brain networks implicated in cognitive decline and other AD symptoms.
What is the overall purpose or intended impact of the FOA?
The purpose is to push the field toward a more precise map of where and why AD-related degeneration starts and spreads, and what differentiates vulnerable versus resilient cell populations and networks during aging and AD. This is intended to support mechanistic insights that can guide more targeted therapeutic strategies.
What activity category and funding category are associated with this opportunity?
The activity category is listed as health, and the opportunity is categorized as discretionary funding.
What CFDA number is associated with this funding opportunity?
The CFDA number listed for this opportunity is 93.866.
Is an award ceiling specified in the provided information?
No award ceiling is specified in the provided data.
How should applicants think about budget and scope if a ceiling is not listed?
Based on the information provided, budgets under the R01 mechanism are typically framed to match the scientific aims and within NIH policy constraints, with applicants requesting the level of support needed to accomplish the proposed objectives.
Who is eligible to apply?
Eligibility is broad and includes many applicant types across government, academia, nonprofit, and industry, as well as additional groups explicitly called out in the FOA.
Are state and local governments eligible?
Yes. Eligible applicants include state governments, county governments, city or township governments, special district governments, and independent school districts.
Are higher education institutions eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are tribal governments and tribal organizations eligible?
Yes. Eligible applicants include Native American tribal governments that are federally recognized and Native American tribal organizations other than federally recognized tribal governments. The FOA also lists Indian/Native American Tribal Governments other than federally recognized among additional eligible applicants.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.
Are nonprofit organizations eligible?
Yes. Eligible applicants include nonprofits with 501(c)(3) status and nonprofits without 501(c)(3) status (in both cases other than institutions of higher education).
Are for-profit organizations eligible, including small businesses?
Yes. Eligible applicants include for-profit organizations other than small businesses, and small businesses.
Are Minority Serving Institutions (MSIs) explicitly included as eligible?
Yes. The FOA explicitly lists Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are listed among additional eligible applicants.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are listed among additional eligible applicants.
Can non-U.S. (foreign) organizations apply?
Yes. The FOA indicates that non-domestic (non-U.S.) entities are eligible, meaning foreign organizations may apply.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are listed among additional eligible applicants.
What is the original closing date shown for this opportunity?
The source information lists an original closing date of 2018-03-06.
What is the creation date shown for this opportunity?
The creation date listed in the source information is 2016-11-03.
Does the FOA connect aging processes to Alzheimers-specific neurodegeneration?
Yes. The FOA describes an interest in understanding biological cascades that link aging processes to Alzheimers-specific neurodegeneration, as part of explaining selective vulnerability.
What kinds of therapeutic or intervention-oriented insights does the FOA aim to enable?
Based on the description provided, the FOA is aligned with identifying targeted intervention strategies, such as protecting high-risk cell types, stabilizing critical circuits, preserving network connectivity, or interrupting the biological cascades that connect aging to AD-related degeneration.
Does the FOA indicate that AD-related degeneration can be mapped as starting and spreading?
Yes. The description emphasizes building a more precise map of where and why AD-related degeneration starts and spreads, and how vulnerability changes over time.
Is this opportunity limited to a single institution type or sector?
No. The eligibility list spans government entities, academic institutions, nonprofits, for-profits, small businesses, tribal entities, community-based organizations, federal agencies, U.S. territories, and non-U.S. entities.
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